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Research

​We are interested in understanding how defects in nuclear envelope proteins lead to cardiomyopathy. We combine multi-disciplinary, state-of-the-art approaches using cells and model organisms to elucidate the key underlying mechanisms.
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​Specifically…

…we use structural biology techniques to reveal how mutations in nuclear envelope proteins affect folding…
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Myoblast stained for a nuclear envelope protein (green), the nuclear lamina (red) and DNA (blue). Super-resolution image generated using the Deltavision OMX System.
​…and combine this with cell biology and biochemistry, to understand the functional consequences of these mutations at cellular and tissue levels…
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Neonatal heart before (left) and after being stained (middle, right panels), for heart cells (red), dying cells (green) and DNA (blue).
​…in addition to using physiological approaches for monitoring heart function of model organisms that are engineered to mimic the cardiomyopathy-causing mutations found in patients.

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Short axis view of the heart using echocardiography, with sizes of the chambers (LVIDd and LVIDs), wall thicknesses (IVSd, LVPWd), function (FS) and heart rate (HR) indicated.
​​Our funding is kindly provided by:
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