We are interested in understanding how defects in nuclear envelope proteins lead to cardiomyopathy. We combine multi-disciplinary, state-of-the-art approaches using cells and model organisms to elucidate the key underlying mechanisms.
Specifically…
…we use structural biology techniques to reveal how mutations in nuclear envelope proteins affect folding…
…we use structural biology techniques to reveal how mutations in nuclear envelope proteins affect folding…
…and combine this with cell biology and biochemistry, to understand the functional consequences of these mutations at cellular and tissue levels…
…in addition to using physiological approaches for monitoring heart function of model organisms that are engineered to mimic the cardiomyopathy-causing mutations found in patients.
Our funding is kindly provided by: